He eventually reaches the Judge's tower where Yuki prepares to exact her revenge, however through an accursed mask the Judge manages to act as a symbiont for The Fallen Engineer, the true antagonist of the plot, and he partakes with The Dishwasher and Yuki in a battle. The Dishwasher leaves her to her mission, as he continues his search for the source of Cyborgs. The two then reconcile, however Yuki remains convinced that her mission for revenge is one that she must carry out alone. Yuki regains conscious and finds The Dishwasher standing over The Creeper's dead body. The Dishwasher finds Yuki being manipulated by The Creeper, but quickly kills The Creeper so as to not having to resort to killing Yuki again. In The Dishwasher's storyline, Chef confronts him, explaining to him that Yuki is being manipulated by The Creeper, who must die if Yuki is to have her freedom. In the end after facing the fact that the world is still in chaos and that her stepbrother is dead, her only care in the world is that she's finally free. Yuki succeeds, and proceeds to kill her final mark, the Judge, who has become a symbiont for The Fallen Engineer. He tells Yuki that the knife she extracted from her nightmares should be taken back and used to murder her inner demon who is driving her to the brink of insanity. Chef then arrives to the scene, explaining to her that killing The Dishwasher shouldn't be possible as the Chef, Dishwasher and Yuki all share the same inhuman blood that makes them unkillable through normal means. The Creeper then appears before Yuki and is killed by her in a fit of rage and hate. The Dishwasher rips the knife out of his body and dies. Yuki becomes distressed but is reassured by him that he's okay with it, as it's only fair she repays him the favor for having killed her once. However she regains conscious and finds out that she inadvertently has stabbed The Dishwasher with it. In Yuki's storyline, she finds herself in another hallucination where she finds a knife and uses it to kill who she believes is her manipulator, The Creeper. They break off midway into separate stories once the two protagonists meet each other for the first time, however. The game is broken up into two solo campaigns that largely run in tandem with each other. During this time The Dishwasher who has relocated himself to the moon finds himself searching for the heart of the new Cyborg movement, following Yuki's blood trail of revenge. She then and there decides to pursue a quest for revenge against the three figures of power known as The Banker, General and Judge, all of whom were responsible for her incarceration. She crashes onto the Moon and wakes up, only to find herself with a chainsaw implant where her arm used to be. With her newfound powers she breaks out of the prison and stows herself away in an escape pod shortly after getting her arm cut off in battle. During her time in the Iffenhaus prison ship she experiences recurring nightmares caused by an entity known as The Creeper, and wakes up to the image of her slaughtering a prison guard. This crime was pinned on Yuki however, who was witnessed escaping the scene, having mysteriously been reanimated. It is revealed that after the events of the first game, The Dishwasher and Chef destroyed the world after it became uninhabitable. The Dishwasher emerges victorious from this battle and Yuki dies in his hands. The game begins with a playable flashback segment of the first game where the player leads The Dishwasher through the Grace Chapel, building up to the boss fight against Yuki. The guitar minigame also makes a return however, the Psycho Picks that were granted in the original game for finishing them do not. A new gameplay feature is the addition of collectible Beads that can be equipped to give various status effects such as improved strength against specific enemies or attacks draining health. Guns are now automatically mapped to function on the right trigger, and normal enemies no longer have exclusive executions as they are all down to weaponry. Combat revisions have been made: now the player can stock up to four weapons at once with the help of two sets of load outs that can be interchanged at all times.

There are five new weapons in the game, including a large syringe dubbed The Painkiller and an oversized pair of scissors titled The Guillotine. Co-op has also been fully integrated into the story-mode allowing for an exclusive campaign. The biggest addition is a new playable character, Yuki, who controls differently from The Dishwasher in combat. Recurring elements from the original include Dish Magic and Shop Bots where one can buy upgrades and items with money received through defeating enemies. The game is a side-scrolling beat 'em up where the player must violently dispense of enemies with the help of numerous weapons.

Gameplay remains largely similar to that of its predecessor.

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